30-Nights Bolivia to Brazil: Highlands & Coastlines - 18-to-Thirtysomethings from $4,161

The entire city of Parati (Paraty) is considered a national monument as it was deemed by UNESCO to be one of the world’s most illustrious examples of Portuguese colonial architecture. A virtual museum within a tropical paradise, it is located southeast of Rio de Janeiro. The streets are lined with beautifully whitewashed buildings and many have colorfully painted trim. Motorized vehicles are forbidden on the majority of the narrow, cobblestone streets, so you can wander freely, absorbed in the tranquility and meticulously preserved architecture. Highlights of this quaint city include numerous churches, in particular the Portuguese Baroque-style Church of Santa Rita, built around 1720. Once all of the city’s beauty is explored, take some time out for a leisurely stroll along the shore or dine at any of the waterfront restaurants serving locally caught fish. There are also several shops in the historic area catering to local artisans and merchants.

In an isolated corner of southwestern Bolivia sits the desert-like landscape of Uyuni. It was founded in 1889 by Bolivian president Anicento Arce who operates a military base outside of the town. Uyuni's economy has blossomed from the many visits to the world's largest salt flats.